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The porcine Major Histocompatibility Complex and related paralogous regions: a review

Patrick Chardon*, Christine Renard, Claire Rogel Gaillard and Marcel Vaiman

Author Affiliations

Laboratoire de radiobiologie et d'étude du génome, Département de génétique animale, Institut national de la recherche agronomique, Commissariat à l'énergie atomique, 78352, Jouy-en-Josas Cedex, France

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Genetics Selection Evolution 2000, 32:109-128  doi:10.1186/1297-9686-32-2-109

The electronic version of this article is the complete one and can be found online at: http://www.gsejournal.org/content/32/2/109


Received:18 November 1999
Accepted:17 January 2000
Published:15 March 2000

© 2000 INRA, EDP Sciences

Abstract

The physical alignment of the entire region of the pig major histocompatibility complex (MHC) has been almost completed. In swine, the MHC is called the SLA (swine leukocyte antigen) and most of its class I region has been sequenced. Over one hundred genes have been characterised, including the classical class I and class I-related genes, as well as the class II gene families. These results in swine provide new evidence for the striking conservation during the evolution of a general MHC framework, and are consistent with the location of the class I genes on segments referred to as permissive places within the MHC class I region. Recent results confirm the involvement of the SLA region in numerous quantitative traits.

Keywords:
pig; major histocompatibility complex; physical map; performance; paralogous regions

Research

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