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Open Access Research

Bayesian QTL mapping using skewed Student-t distributions

Peter von Rohr12 and Ina Hoeschele1*

Author Affiliations

1 Departments of Dairy Science and Statistics, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0315, USA

2 Institute of Animal Sciences, Animal Breeding, Swiss Federal Institute of Technology (ETH), Zurich, Switzerland

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Genetics Selection Evolution 2002, 34:1-21  doi:10.1186/1297-9686-34-1-1


The electronic version of this article is the complete one and can be found online at: http://www.gsejournal.org/content/34/1/1


Received:23 April 2001
Accepted:17 September 2001
Published:15 January 2002

© 2002 INRA, EDP Sciences

Abstract

In most QTL mapping studies, phenotypes are assumed to follow normal distributions. Deviations from this assumption may lead to detection of false positive QTL. To improve the robustness of Bayesian QTL mapping methods, the normal distribution for residuals is replaced with a skewed Student-t distribution. The latter distribution is able to account for both heavy tails and skewness, and both components are each controlled by a single parameter. The Bayesian QTL mapping method using a skewed Student-t distribution is evaluated with simulated data sets under five different scenarios of residual error distributions and QTL effects.

Keywords:
Bayesian QTL mapping; skewed Student-t distribution; Metropolis-Hastings sampling

Research

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