This article is part of the supplement: Second International Symposium on Candidate Genes for Animal Health. 16-18 August 2002, Montpelier - France
Research
Association between the MHC gene region and variation of serum IgE levels against specific mould allergens in the horse
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* Corresponding author: Eliane Marti eliane.marti@itz.unibe.ch
1 Animal Science Department, Faculty of Agriculture, University of Zagreb, Svetosimunska 25, 10000-Zagreb, Croatia
2 Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164-7040, USA
3 Division of Immunogenetics, Institute of Animal Breeding, University of Berne, Bremgartenstrasse 109 A, 3012-Berne, Switzerland
4 Ludwig-Boltzmann-Institute for Cyto-, Immuno- and Molecular Genetic Research, Veterinärplatz 1, 1210-Vienna, Austria
5 Animal Health Trust, Newmarket, Suffolk CB8 7UU, UKAnimal Health Trust, Newmarket, Suffolk CB8 7UU, UK
6 Swiss Institute of Allergy and Asthma Research (SIAF), Obere Strasse 22, 7270-Davos, Switzerland
7 Department of Livestock Science, University of Agricultural Sciences, Gregor-Mendel-Strasse 33, 1180-Vienna, Austria
8 Division of Clinical Immunology, Department of Clinical Veterinary Medicine, University of Berne, Länggass-Strasse 124, 3012-Berne, Switzerland
Genetics Selection Evolution 2003, 35(Suppl 1):S177-S190 doi:10.1186/1297-9686-35-S1-S177
The electronic version of this article is the complete one and can be found online at: http://www.gsejournal.org/content/35/S1/S177
| Accepted: | 26 February 2003 |
| Published: | 15 June 2003 |
© 2003 INRA, EDP Sciences
Abstract
To investigate whether the equine major histocompatibility complex (MHC) gene region influences the production of mould-specific immunoglobulin E antibodies (IgE), alleles of the equine leukocyte antigen (ELA-A) locus and three microsatellite markers (UM-011, HTG-05 and HMS-42) located on the same chromosome as the equine MHC were determined in 448 Lipizzan horses. Statistical analyses based on composite models, showed significant associations of the ELA-A and UM-011 loci with IgE titres against the recombinant Aspergillus fumigatus 7 antigen (rAsp f 7). UM-011 was also significantly associated with IgE titres against the recombinant Aspergillus fumigatus 8 antigen (rAsp f 8). In addition to the loci mentioned above, the MHC class II DQA and DRA loci were determined in 76 Lipizzans from one stud. For IgE levels against rAsp f 7, the composite model showed the strongest association for DQA (P < 0.01) while for rAsp f 8 specific IgE levels, similarly to the results found with all 448 horses, the strongest association was found with UM-011 (P = 0.01), which is closely linked with the MHC class II DRB locus. These results suggest that the equine MHC gene region and possibly MHC class II loci, influence the specific IgE response in the horse. However, although the strongest associations were found with DQA and UM-011, this study did not distinguish if the observed effects were due to the MHC itself or to other tightly linked genes.
Keywords:
horse; major histocompatibility complex; immunoglobulin E; specific mould allergenResearch
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