Research
NNAT and DIRAS3 genes are paternally expressed in pigs
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* Corresponding author: Chang-Yan Deng zfw2004790921521@126.com
1 Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education and Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, Huazhong Agriculture University, Wuhan, PR China
2 Department of Bio-engineering, College of Animal Sciences, Southwest University, Chongqing, 400716, PR China
Genetics Selection Evolution 2007, 39:599-607 doi:10.1186/1297-9686-39-5-599
The electronic version of this article is the complete one and can be found online at: http://www.gsejournal.org/content/39/5/599
| Received: | 24 December 2006 |
| Accepted: | 25 April 2007 |
| Published: | 27 September 2007 |
© 2007 INRA, EDP Sciences
Abstract
Although expression and epigenetic differences of imprinted genes have been extensively characterised in man and the mouse, little is known on livestock species. In this study, the polymorphism-based approach was used to detect the imprinting status of NNAT and DIRAS3 genes in five heterozygous pigs (based on SNP) of Large White and Meishan F1 hybrids. The results show that both genes were paternally expressed in all the tested tissues (heart, liver, spleen, lung, kidney, stomach, small intestine, skeletal muscle, fat, uterus, ovary and pituitary). In addition, the NNAT gene had two transcripts in all tested tissues, which is consistent with its counterpart in man and cattle.
Keywords:
pig; NNAT; DIRAS3; imprinting; paternally expressedResearch
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