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Evolution of the polymorphism at molecular markers in QTL and non-QTL regions in selected chicken lines (Open Access publication)

Genetics Selection Evolution volume 40, Article number: 639 (2008) Cite this article

Abstract

We investigated the joint evolution of neutral and selected genomic regions in three chicken lines selected for immune response and in one control line. We compared the evolution of polymorphism of 21 supposedly neutral microsatellite markers versus 30 microsatellite markers located in seven quantitative trait loci (QTL) regions. Divergence of lines was observed by factor analysis. Five supposedly neutral markers and 12 markers in theQTL regions showed Fst values greater than 0.15. However, the non-significant difference (P > 0.05) between matrices of genetic distances based on genotypes at supposedly neutral markers on the one hand, and at markers in QTL regions, on the other hand, showed that none of the markers in the QTL regions were influenced by selection. A supposedly neutral marker and a marker located in the QTL region on chromosome 14 showed temporal variations in allele frequencies that could not be explained by drift only. Finally, to confirm thatmarkers located inQTL regions on chromosomes 1, 7 and 14were under the influence of selection, simulations were performed using haplotype dropping along the existing pedigree. In the zone located on chromosome 14, the simulation results confirmed that selection had an effect on the evolution of polymorphism of markers within the zone.

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Authors and Affiliations

  1. Génétique et Diversité Animales UMR1236, INRA/AgroParisTech, 78352, Jouy-en-Josas, France

    Valérie Loywyck, Bertrand Bed'hom, Marie-Hélène Pinard-van der Laan & Étienne Verrier

  2. Génétique Cellulaire UR444, INRA, 31326, Castanet-Tolosan, France

    Frédérique Pitel

  3. Animal Breeding and Genomics Group, Wageningen University, 6700, AH, Wageningen, The Netherlands

    Piter Bijma

Authors
  1. Valérie Loywyck
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  2. Bertrand Bed'hom
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  3. Marie-Hélène Pinard-van der Laan
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  4. Frédérique Pitel
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  5. Étienne Verrier
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  6. Piter Bijma
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Corresponding author

Correspondence to Valérie Loywyck.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/2.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Loywyck, V., Bed'hom, B., Pinard-van der Laan, MH. et al. Evolution of the polymorphism at molecular markers in QTL and non-QTL regions in selected chicken lines (Open Access publication). Genet Sel Evol 40, 639 (2008). https://doi.org/10.1186/1297-9686-40-6-639

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  • DOI: https://doi.org/10.1186/1297-9686-40-6-639

Keywords

Genetics Selection Evolution

ISSN: 1297-9686