Genetics Selection Evolution

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Mapping quantitative trait loci (QTL) in sheep. I. A new male framework linkage map and QTL for growth rate and body weight

Herman W Raadsma1*, Peter C Thomson1, Kyall R Zenger1, Colin Cavanagh1,2, Mary K Lam1, Elisabeth Jonas1, Marilyn Jones1, Gina Attard1, David Palmer1 and Frank W Nicholas1

Author Affiliations

1 ReproGen – Advanced Technologies in Animal Genetics and Reproduction, Faculty of Veterinary Science, University of Sydney, 425 Werombi Road, Camden NSW 2570, Australia

2 Commonwealth Scientific and Industrial Research Organisation Plant Industry, Black Mountain, ACT 2601, Australia

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Genetics Selection Evolution 2009, 41:34 doi:10.1186/1297-9686-41-34

Published: 24 April 2009

Additional files

Additional file 1:

Traits measured in the Awassi-Merino resource flock. A list of all traits included the traits used for the analysis in the present paper, which were recorded in the sheep resource population used in the present study.

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Additional file 2:

Methodology QTL-MLE. A detailed description of the QTL-MLE methodology which was developed by PCT and was used for the analysis shown here.

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Additional file 3:

LOD score difference between the best and second best map order. This tables shows the differences of the LOD scored between the best and the second best map order, shown are the results on each autosome.

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Additional file 4:

Marker information for the Awassi × Merino map. The figures shown here summarize the markers used in the study and compare the framework map described in the Awassi × Merino resource population with the published map. Further the identified linkage regions from the present study and QTL and candidate genes from various references are shown. All figures were designed using the MapChart software described by Voorrips R.E. in 2002 (MapChart: Software for the graphical presentation of linkage maps and QTLs. The Journal of Heredity 93 (1): 77–78).

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Additional file 5:

Summary of results using QTL-MLE and QTL Express. Values in table are estimated QTL positions (cM). This table shows the average QTL positions of all QTL presented here using both programs QTL-MLE and QTL Express. It summarizes and compares all results observed in the resource population for the growth and weight traits.

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Additional file 6:

3D surface plot of the variance ratio test statistic for a two-QTL model. This figure shows the 3D surface plot for a two-QTL model for GR56-83 adj for BW56 on OAR3. The values of the plot are generated by QTL Express.

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Additional file 7:

Comparison of the QTL analysis results in the present studies with other results and possible candidate genes. This table describes QTL identified in other studies which are located in comparable regions to the linkage regions identified using animals of the Awassi × Merino population. Further possible candidate genes are described. The list of references for these data is attached following the table.

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